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An alumnus of Cambridge investigates UPCT obtaining cells to treat liver failure and diabetes (17/09/2014)

Telecommunication studying to work in the lab for Regenerative Medicine, University of Cambridge.

The case of the alumni of the Polytechnic University of Cartagena (UPCT) Bayonas Pedro Madrigal, in a few months will read his doctoral thesis in bioinformatics, exemplifies the possibilities of transferring information technology and communications to the field of health.

"Today science is more multidisciplinary than ever," said Madrigal.

"The development of my final project in the field of image processing in radiology allowed me to get in touch with the world of medicine, which led me to reflect and question me that way engineering and computer science could enhance the prevention, diagnosis and treatment of diseases, "says the graduate of the Polytechnic.

After finishing Telecommunication Engineering in 2010, Madrigal got a Marie Curie Fellowship of the European Union to pursue a Ph.D. in bioinformatics at the Academy of Sciences of Poland in which he combined protocols sequencing DNA fragments with bioinformatics algorithms and statistical analysis with supercomputing to demonstrate the relationship between certain proteins and chromatin state in Arabidopsis, a small plant that is used as a model in genetics.

The ability to identify signals when various proteins interact with DNA which is implemented in the Cambridge Laboratory for Regenerative Medicine and the Department of Computational Genomics Sanger Institute.

"In the group led by Dr. Ludovic Vallier study the mechanisms of cell differentiation and are specialized in obtaining pancreatic and liver cells with the aim of later use in cell therapy in liver failure and type 1 diabetes target more long term is the laboratory production of human organs with the patient's DNA, "says Madrigal.

The alumnus UPCT is responsible for mathematical and statistical analysis of a large volume of data from different experiments DNA sequencing using supercomputers.

"This type of analysis performed during cell differentiation are essential, for example, be able to generate in the laboratory and much more functional pancreatic cells 'similar' to natural.

We also study how variations in DNA regulate gene expression, and how it correlates with evolutionary processes and pathologies in humans, "he continues.

Another line of research that is involved Madrigal improved methods of reprogramming adult cells to induced pluripotent stem cells, "allowing cell lines derived from a similar embryonic state without the inconvenience posed ethical use of stem cells and using the same genetic background of the patient, "he adds.

Murciano 29, Madrigal points out that "the graduates of the School of Teleco UPCT have adequate preparation and to apply their knowledge in any scientific field skills" and defends research as "a creative work interesting alternative, and sometimes full of satisfactions.

Although in many cases entails having to walk away from your family and your land to emigrate to other countries who have recognized that the future competitiveness and involves research and technological innovation, "he laments.

At the University of Cambridge, the best in Europe and fifth in the world according to the Shanghai ranking, is also investigating another graduate of the School of Teleco UPCT, David Ródenas.

Source: UPCT

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